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Deodhar, M. N.
- Simultaneous Spectrophotometric Estimation of Ezetimibe and Atorvastatin in Pharmaceutical Dosage Form
Abstract Views :152 |
PDF Views:0
Authors
V. P. Godse
1,
M. N. Deodhar
1,
A. V. Bhosale
1,
R. A. Sonawane
1,
P. S. Sakpal
1,
D. D. Borkar
1,
Y. S. Bafana
1
Affiliations
1 Dept. of Pharmaceutical Analysis, Seth Govind Raghunath Sable College of Pharmacy, Saswad, Pune-412301, IN
1 Dept. of Pharmaceutical Analysis, Seth Govind Raghunath Sable College of Pharmacy, Saswad, Pune-412301, IN
Source
Asian Journal of Research in Chemistry, Vol 2, No 1 (2009), Pagination: 86-89Abstract
Two simple, sensitive accurate, precise, rapid and economical methods were developed for the estimation of Ezetimibe and Atorvastatin in two components solid dosage form. First method is based on simultaneous equations and second method is based on absorbance ratio method. Ezetimibe has absorbance maxima at 232.5 nm and Atorvastatin has Absorbance maxima at 246.5 nm in methanol. The linearity was obtained in the concentration range 5-30 mcg/ml for both Ezetimibe and Atorvastatin. In the first method the concentration of the drugs were determined by using simultaneous equations and in second method, concentration of the drugs were determined by using ratio of absorbance at iso-absorptive point and at λmax of one of the drug. The results of analysis have been validated statistically and by recovery studies.Keywords
Ezetimibe, Atorvastatin, Simultaneous Equations, Absorbance Ratio, Iso-Absorptive Point.- Reverse Phase HPLC Method for Determination of Aceclofenac and Paracetamol in Tablet Dosage Form
Abstract Views :165 |
PDF Views:0
Authors
V. P. Godse
1,
M. N. Deodhar
1,
A. V. Bhosale
1,
R. A. Sonawane
1,
P. S. Sakpal
1,
D. D. Borkar
1,
Y. S. Bafana
1
Affiliations
1 Dept. of Pharmaceutical Analysis, Seth Govind Raghunath Sable College of Pharmacy, Saswad, Pune-412301, IN
1 Dept. of Pharmaceutical Analysis, Seth Govind Raghunath Sable College of Pharmacy, Saswad, Pune-412301, IN
Source
Asian Journal of Research in Chemistry, Vol 2, No 1 (2009), Pagination: 37-40Abstract
A simple, rapid and selective HPLC method has been developed for quantitation of aceclofenac and paracetamol from bulk drug and pharmaceutical formulations using a mobile phase consisting mixture of methanol and water (70:30 v/v) at the flow rate of 1 mL/min. An ODS C-18 (Intersile 25 cm×4.6 mm, 10 μm.) column was used as stationary phase. The retention time of aceclofenac and paracetamol were 1.8 min. and 2.7 min. respectively. Linearity was observed in the concentration range of 2-50 μg/mL for aceclofenac and 5-50 μg/mL for paracetamol. Percent recoveries obtained for aceclofenac and paracetamol were 100.6 and 100.7 respectively. The proposed method is precise, accurate, selective and rapid for the simultaneous determination of aceclofenac and paracetamol.Keywords
Aceclofenac, Paracetamol, HPLC Method.- Validated Simultaneous UV Spectrophotometric Methods for Estimation of Tramadol Hydrochloride and Ketorolac Tromethamine in Bulk and Marketed Capsule Formulation
Abstract Views :740 |
PDF Views:1
Authors
Affiliations
1 J.N.T. University, Hyderabad and PES Modern College of Pharmacy for Ladies, Pune, IN
2 J.N.T. University, Hyderabad and S.G.R.S. College of Pharmacy, Pune, IN
3 Siddhartha Institute of Pharmacy, J.N.T. University, Hyderabad, IN
1 J.N.T. University, Hyderabad and PES Modern College of Pharmacy for Ladies, Pune, IN
2 J.N.T. University, Hyderabad and S.G.R.S. College of Pharmacy, Pune, IN
3 Siddhartha Institute of Pharmacy, J.N.T. University, Hyderabad, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 7, No 4 (2017), Pagination: 203-208Abstract
The present study describes new, simple, rapid and novel spectrophotometric methods for simultaneous estimation of Tramadol Hydrochloride and Ketorolac Tromethamine in bulk and capsule formulation. The combination was analysed by simultaneous equation method (Method A), Absorbance correction method (Method B) and First order derivative spectroscopic method (Method C). Method A involved measurement of absorbance at two wavelengths, 271 nm and 246 nm, λmax of Tramadol hydrochloride and Ketorolac tromethamine respectively. For method B, wavelengths 331 nm (for determination of Ketorolac tromethamine) and 271 nm were used. For method C, wavelengths 339.2 nm (Zero crossing of Tramadol hydrochloride) and 229.4 nm (Zero crossing of Ketorolac tromethamine) were used for determination of Ketorolac tromethamine and Tramadol hydrochloride respectively. Beer’s law was obeyed in concentration range of 5-50 μg/ ml and 2-20 μg/ ml for Tramadol hydrochloride and Ketorolac tromethamine respectively by all the methods. Method C was found to be more simple and sensitive. The proposed methods are recommended for routine analysis of pharmaceutical formulations due to their specificity, rapidity, simplicity and accuracy. These methods were validated for linearity, accuracy and precision as per ICH guidelines.Keywords
Tramadol Hydrochloride, Ketorolac Tromethamine, UV Spectroscopy.References
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